It's Amazing

The Octopus trial has reached the point of the 1st review or "checkpoint" – results will be announced mid-September 2026.

The Octopus trial team are assessing if alpha-lipoic acid and/or metformin appears to be effective, based on MRI scans and clinical assessments that participants have completed.

With this in mind, new registrations to the Octopus trial are being halted until it is known what comes next. The following things could happen:

• Two of the treatment existing arms are showing promise and they will continue, with screening re-starting in the end of September 2026
• One of the existing treatment arms are showing promise and they will continue, with screening re-starting in September 2026. The other existing arm will stop, and participants will come off this treatment.
• Neither show promise and the "recruitment holiday" will extend until Octopus can start the new treatment arms, which should be ready by December 2026.

There will be plenty of publicity once these results are known, so please check back then as we will be accepting new registrations or please take a look at www.ms-octopus.info.

The first checkpoint is shown as "Analysis of Stage 1 data" in the diagram below.